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Issue 5, 2017
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Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

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Abstract

Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation.

Graphical abstract: Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

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Article information


Submitted
30 Nov 2016
Accepted
03 Jan 2017
First published
04 Jan 2017

Org. Biomol. Chem., 2017,15, 1100-1105
Article type
Communication

Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

T. Hanauer, R. J. Hopkinson, K. Patel, Y. Li, D. Correddu, A. Kawamura, V. Sarojini, I. K. H. Leung and T. Gruber, Org. Biomol. Chem., 2017, 15, 1100
DOI: 10.1039/C6OB02616H

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