Issue 4, 2017
From the journal:

Organic & Biomolecular Chemistry

Hypervalent iodine-triggered transformation of homopropargyl sulfonamides into dihalo-2,3-dihydropyrroles†

Ruijia Wang,a   Yuejun OuYang,b   Chonghui Xu,a   Niannian Yi,a   Jun Jiang,a   Wei Deng,*a   Zebing Zenga  and  Jiannan Xiang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China
E-mail: weideng@hnu.edu.cn

b Huaihua Key Laboratory of Functional Inorganic & Polymaterial Materials (Huaihua University), Huaihua 418000, P. R. China

Abstract

A novel hypervalent iodine-triggered hydroamination of homopropargyl sulfonamides with copper halides to obtain dihalo-2,3-dihydropyrroles was efficiently developed. The reaction can provide access to chloro/bromo-cyclization extended from iodocyclization to prepare potentially useful halogenated building blocks for drug development with broad functional group tolerance and high yield yet in a short time.

Graphical abstract: Hypervalent iodine-triggered transformation of homopropargyl sulfonamides into dihalo-2,3-dihydropyrroles

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Article information

DOI
https://doi.org/10.1039/C6OB02536F
Article type
Communication
Submitted
18 Nov 2016
Accepted
20 Dec 2016
First published
20 Dec 2016

Org. Biomol. Chem., 2017,15, 796-800

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Hypervalent iodine-triggered transformation of homopropargyl sulfonamides into dihalo-2,3-dihydropyrroles

R. Wang, Y. OuYang, C. Xu, N. Yi, J. Jiang, W. Deng, Z. Zeng and J. Xiang, Org. Biomol. Chem., 2017, 15, 796 DOI: 10.1039/C6OB02536F

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