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Enantiospecific total syntheses of spiromeroterpenoid natural products (−)-F1839-I and (−)-corallidictyals B and D were achieved using the environmentally benign and highly atom economical Lewis acid catalysed Friedel–Crafts reaction and a highly regio- and stereoselective spirocyclic C–O bond formation reaction.

Graphical abstract: Enantiospecific total syntheses of meroterpenoids (−)-F1839-I and (−)-corallidictyals B and D

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