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Issue 4, 2017
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A highly selective fluorescent probe for Fe3+ in living cells: a stress induced cell based model study

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Abstract

A rhodamine–phenanthroline dyad based fluorescent probe 4 has been designed and synthesized which selectively monitors Fe3+ ions among the various metal ions tested. Furthermore, probe 4 has been explored for monitoring of dynamic changes in the Fe3+ ion level under aggressive Fenton reaction conditions using a cell based model study. More significantly, probe 4 has also been utilized for real time imaging of endogenous Fe3+ ions in living C6 cell lines, the results of which demonstrated that probe 4 acts as an efficient fluorescent tool for Fe3+ ion detection in biological systems.

Graphical abstract: A highly selective fluorescent probe for Fe3+ in living cells: a stress induced cell based model study

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Supplementary files

Article information


Submitted
10 Oct 2016
Accepted
22 Dec 2016
First published
23 Dec 2016

Org. Biomol. Chem., 2017,15, 1006-1012
Article type
Paper

A highly selective fluorescent probe for Fe3+ in living cells: a stress induced cell based model study

N. Sharma, S. I. Reja, N. Gupta, V. Bhalla, D. Kaur, S. Arora and M. Kumar, Org. Biomol. Chem., 2017, 15, 1006
DOI: 10.1039/C6OB02209J

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