Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 2, 2017
Previous Article Next Article

The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa

Author affiliations

Abstract

The ‘perfect storm’ of increasing bacterial antibiotic resistance and a decline in the discovery of new antibiotics, has made it necessary to search for new and innovative strategies to treat bacterial infections. Interruption of bacterial cell-to-cell communication signalling (Quorum Sensing), thus neutralizing virulence in pathogenic bacteria, is a growing area. 2-Alkyl-4-quinolones, HHQ and PQS, play a key role in the quorum sensing circuitry of P. aeruginosa. We report a new set of isosteres of 2-heptyl-6-nitroquinolin-4-one, with alterations at C-3, and evaluate the key structural requirements for agonistic and antagonistic activity in Pseudomonas aeruginosa.

Graphical abstract: The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa

Back to tab navigation

Supplementary files

Article information


Submitted
01 Sep 2016
Accepted
24 Nov 2016
First published
30 Nov 2016

Org. Biomol. Chem., 2017,15, 306-310
Article type
Communication

The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa

R. Shanahan, F. J. Reen, R. Cano, F. O'Gara and G. P. McGlacken, Org. Biomol. Chem., 2017, 15, 306
DOI: 10.1039/C6OB01930G

Social activity

Search articles by author

Spotlight

Advertisements