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Issue 3, 2018
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Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field

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Abstract

A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enhanced kinetics. MaBiDz was demonstrated here as a cellular sensor for rapid detection and imaging of a target mRNA biomarker for metastatic breast cancer, and its function shows potential to be expanded as a biomimetic organelle that can downregulate the activity of a target mRNA biomarker.

Graphical abstract: Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field

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Supplementary files

Article information


Submitted
16 Nov 2017
Accepted
18 Dec 2017
First published
18 Dec 2017

Nanoscale, 2018,10, 1356-1365
Article type
Paper

Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field

S. F. Bakshi, N. Guz, A. Zakharchenko, H. Deng, A. V. Tumanov, C. D. Woodworth, S. Minko, D. M. Kolpashchikov and E. Katz, Nanoscale, 2018, 10, 1356
DOI: 10.1039/C7NR08581H

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