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Issue 31, 2017
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Photosensitizer localization in amphiphilic block copolymers controls photodynamic therapy efficacy

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Abstract

Localization of the photosensitizer conjugation site in amphiphilic block copolymers is shown to have a great impact on photodynamic therapy efficiency. To this end, an asymmetric multifunctional derivative of the azadipyrromethene boron difluoride chelate (aza-BODIPY) was synthesized and inserted at specific locations in polypeptide-based rod-coil amphiphilic block copolymers. A study of the photophysical properties of the vesicle nanocarriers, obtained by self-assembly of these copolymers, as well as in vitro tests on two cancer cell lines were performed. This study aims at providing guidelines for the optimization of the synthetic design of therapeutic nanomedicines with minimal amounts of photosensitive molecules.

Graphical abstract: Photosensitizer localization in amphiphilic block copolymers controls photodynamic therapy efficacy

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Publication details

The article was received on 19 Jun 2017, accepted on 18 Jul 2017 and first published on 20 Jul 2017


Article type: Paper
DOI: 10.1039/C7NR04403H
Nanoscale, 2017,9, 11180-11186

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    Photosensitizer localization in amphiphilic block copolymers controls photodynamic therapy efficacy

    V. Ibrahimova, S. A. Denisov, K. Vanvarenberg, P. Verwilst, V. Préat, J. Guigner, N. D. McClenaghan, S. Lecommandoux and C. Fustin, Nanoscale, 2017, 9, 11180
    DOI: 10.1039/C7NR04403H

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