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Issue 31, 2017
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Probing T1T2 interactions and their imaging implications through a thermally responsive nanoprobe

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Abstract

The complex and specialised diagnostic process through magnetic resonance imaging (MRI) could be simplified with the implementation of dual T1T2 contrast agents. T1- and T2-weighted MR are compatible modalities, and co-acquisition of contrast enhanced images in both T1 and T2 will drastically reduce artefacts and provide double-checked results. To date, efforts in the development of dual MRI probes have provided inconsistent results. Here we present the preparation and relaxometric study of a dual T1T2 MRI probe based on superparamagnetic nanoparticles, paramagnetic Gd3+ chelates and pNIPAM (poly(N-isopropylacrylamide)), in which the distance between paramagnetic and superparamagnetic species can be modulated externally via temperature variations. Such a probe alleviates traditional nanotechnology limitations (e.g. batch to batch variability) as comparisons can be established within a single probe.

Graphical abstract: Probing T1–T2 interactions and their imaging implications through a thermally responsive nanoprobe

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Article information


Submitted
10 Mar 2017
Accepted
30 Jun 2017
First published
01 Aug 2017

Nanoscale, 2017,9, 11318-11326
Article type
Paper

Probing T1T2 interactions and their imaging implications through a thermally responsive nanoprobe

J. Gallo, B. I. Harriss, J. Hernández-Gil, M. Bañobre-López and N. J. Long, Nanoscale, 2017, 9, 11318
DOI: 10.1039/C7NR01733B

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