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Issue 14, 2017
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Ultralow-power near-infrared excited neodymium-doped nanoparticles for long-term in vivo bioimaging

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Abstract

Lanthanide-doped luminescent nanoparticles with both emission and excitation in the near-infrared (NIR-to-NIR) region hold great promise for bioimaging. Herein, core@shell structured LiLuF4:Nd@LiLuF4 (named as Nd@Lu) nanoparticles (NPs) with highly efficient NIR emission were developed for high-performance in vivo bioimaging. Strikingly, the absolute quantum yield of Nd@Lu NPs reached as high as 32%. After coating with polyethylene glycol (PEG), the water-dispersible Nd@Lu NPs showed good bio-compatibility and low toxicity. With efficient NIR emission, the Nd@Lu NPs were clearly detectable in tissues at depths of up to 20 mm. In addition, long-term in vivo biodistribution with a high signal-to-noise ratio of 25.1 was distinctly tracked upon an ultralow-power-density excitation (10 mW cm−2) of 732 nm for the first time.

Graphical abstract: Ultralow-power near-infrared excited neodymium-doped nanoparticles for long-term in vivo bioimaging

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Supplementary files

Article information


Submitted
25 Jan 2017
Accepted
10 Mar 2017
First published
15 Mar 2017

Nanoscale, 2017,9, 4660-4664
Article type
Communication

Ultralow-power near-infrared excited neodymium-doped nanoparticles for long-term in vivo bioimaging

Q. Qin, P. Zhang, L. Sun, S. Shi, N. Chen, H. Dong, X. Zheng, L. Li and C. Yan, Nanoscale, 2017, 9, 4660
DOI: 10.1039/C7NR00606C

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