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Issue 6, 2017
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Protein corona composition of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles correlates strongly with the amino acid composition of the protein surface

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Abstract

Extensive molecular dynamics simulations reveal that the interactions between proteins and poly(ethylene glycol) (PEG) can be described in terms of the surface composition of the proteins. PEG molecules accumulate around non-polar residues while avoiding the polar ones. A solvent-accessible-surface-area model of protein adsorption accurately fits a large set of data on the composition of the protein corona of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles recently obtained by label-free proteomic mass spectrometry.

Graphical abstract: Protein corona composition of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles correlates strongly with the amino acid composition of the protein surface

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Article information


Submitted
05 Sep 2016
Accepted
04 Jan 2017
First published
05 Jan 2017

This article is Open Access

Nanoscale, 2017,9, 2138-2144
Article type
Communication

Protein corona composition of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles correlates strongly with the amino acid composition of the protein surface

G. Settanni, J. Zhou, T. Suo, S. Schöttler, K. Landfester, F. Schmid and V. Mailänder, Nanoscale, 2017, 9, 2138
DOI: 10.1039/C6NR07022A

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