Issue 10, 2017

Catalytic macrolactonizations for natural product synthesis

Abstract

Covering: 2000 to 2017

Macrolactones are privileged structural motifs in many functional molecules, particularly natural products and pharmaceutical molecules. They are commonly synthesized from the corresponding seco acids with various stoichiometric activating reagents to promote the formation of the macrocycle. Advances in new methods and strategies for synthesizing macrolactones have been made over the years to improve the overall synthetic efficiency and economy. This highlight focuses on the recent developments of catalytic macrolactonization methods and strategies without the use of seco acids and their applications in natural product total synthesis. In particular, catalytic C–H macrolactonization, enantioselective Rh-catalyzed redox-neutral allene-acid cyclization, catalytic carbonylative macrolactonization, and NHC-catalyzed oxidative macrolactonization are highlighted.

Graphical abstract: Catalytic macrolactonizations for natural product synthesis

Article information

Article type
Highlight
Submitted
07 Jul 2017
First published
30 Aug 2017

Nat. Prod. Rep., 2017,34, 1185-1192

Catalytic macrolactonizations for natural product synthesis

Y. Li, X. Yin and M. Dai, Nat. Prod. Rep., 2017, 34, 1185 DOI: 10.1039/C7NP00038C

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