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Issue 2, 2017
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Natural products as mediators of disease

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Abstract

Covering: up to 2016

Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.

Graphical abstract: Natural products as mediators of disease

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Article information


Submitted
19 May 2016
First published
22 Nov 2016

Nat. Prod. Rep., 2017,34, 194-219
Article type
Review Article
Author version available

Natural products as mediators of disease

N. Garg, T. Luzzatto-Knaan, A. V. Melnik, A. M. Caraballo-Rodríguez, D. J. Floros, D. Petras, R. Gregor, P. C. Dorrestein and V. V. Phelan, Nat. Prod. Rep., 2017, 34, 194
DOI: 10.1039/C6NP00063K

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