A simple and facile NMR method for the determination of hydrogen bonding by amide N–H protons in protein models and other compounds
Abstract
It is shown that measurements of the 1H chemical shifts of amide N–H protons in chloroform and in DMSO solvents are sufficient to determine the extent of hydrogen bonding of the N–H protons in a variety of compounds containing the amide group. Two recent examples are presented from protein and structural chemistry.