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Issue 2, 2017
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Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

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Abstract

Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric ‘gates’ to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.

Graphical abstract: Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

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Supplementary files

Article information


Submitted
11 Nov 2016
Accepted
14 Dec 2016
First published
14 Dec 2016

This article is Open Access

Nanoscale Horiz., 2017,2, 106-109
Article type
Communication

Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

S. Won, S. Richards, M. Walker and M. I. Gibson, Nanoscale Horiz., 2017, 2, 106
DOI: 10.1039/C6NH00202A

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