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Issue 2, 2017
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Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

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Abstract

Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric ‘gates’ to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.

Graphical abstract: Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

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Publication details

The article was received on 11 Nov 2016, accepted on 14 Dec 2016 and first published on 14 Dec 2016


Article type: Communication
DOI: 10.1039/C6NH00202A
Nanoscale Horiz., 2017,2, 106-109
  • Open access: Creative Commons BY license
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    Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

    S. Won, S. Richards, M. Walker and M. I. Gibson, Nanoscale Horiz., 2017, 2, 106
    DOI: 10.1039/C6NH00202A

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