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Issue 4, 2017
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Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research

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Abstract

Mass spectrometry imaging is being increasingly used in metal-based anticancer drug development to study elemental and/or molecular drug distributions in different biological systems. The main analytical tools employed are SIMS (especially nanoSIMS), LA-ICP-MSI and MALDI-MSI as well as a combination of complementary imaging techniques. Main challenges are appropriate sample preparation methods, reliable and validated quantification strategies and a trade-off between sensitivity and spatial resolution. So far, research has mostly focused on the development of analytical methods for imaging with the long term goal to study drug uptake into tumor tissue and toxicity affected organs and to identify cellular targets of metal-based drugs. In this review we cover the technological features of the mass spectrometry imaging methods used and give an overview of the applications in metal-based anticancer drug research as well as some future perspectives.

Graphical abstract: Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research

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Article information


Submitted
10 Oct 2016
Accepted
20 Jan 2017
First published
25 Jan 2017

Metallomics, 2017,9, 365-381
Article type
Tutorial Review

Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research

R. F. S. Lee, S. Theiner, A. Meibom, G. Koellensperger, B. K. Keppler and P. J. Dyson, Metallomics, 2017, 9, 365
DOI: 10.1039/C6MT00231E

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