Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 5, 2017
Previous Article Next Article

Modulating the catalytic activity of enzyme-like nanoparticles through their surface functionalization

Author affiliations

Abstract

The inclusion of transition metal catalysts into nanoparticle scaffolds permits the creation of catalytic nanosystems (nanozymes) able to imitate the behaviour of natural enzymes. Here we report the fabrication of a family of nanozymes comprised of bioorthogonal ruthenium catalysts inserted in the protective monolayer of gold nanoparticles. By introducing simple modifications to the functional groups at the surface of the nanozymes, we have demonstrated control over the kinetic mechanism of our system. Cationic nanozymes with hydrophobic surface functionalities tend to replicate the classical Michaelis Menten model, while those with polar groups display substrate inhibition behaviour, a key mechanism present in 20% of natural enzymes. The structural parameters described herein can be used for creating artificial nanosystems that mimic the complexity observed in cell machinery.

Graphical abstract: Modulating the catalytic activity of enzyme-like nanoparticles through their surface functionalization

Back to tab navigation

Supplementary files

Article information


Submitted
11 Jul 2017
Accepted
24 Oct 2017
First published
24 Oct 2017

Mol. Syst. Des. Eng., 2017,2, 624-628
Article type
Paper

Modulating the catalytic activity of enzyme-like nanoparticles through their surface functionalization

R. Cao-Milán, L. D. He, S. Shorkey, G. Y. Tonga, L. Wang, X. Zhang, I. Uddin, R. Das, M. Sulak and V. M. Rotello, Mol. Syst. Des. Eng., 2017, 2, 624
DOI: 10.1039/C7ME00055C

Social activity

Search articles by author

Spotlight

Advertisements