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Issue 11, 2017
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Benzisoxazole: a privileged scaffold for medicinal chemistry

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The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. This review examines the state of the art in medicinal chemistry as it relates to the comprehensive and general summary of the different benzisoxazole analogs, their use as starting building blocks of multifarious architectures on scales sufficient to drive human drug trials. The number of reports describing benzisoxazole-containing highly active compounds leads to the expectation that this scaffold will further emerge as a potential candidate in the field of drug discovery.

Graphical abstract: Benzisoxazole: a privileged scaffold for medicinal chemistry

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Publication details

The article was received on 01 Sep 2017, accepted on 05 Oct 2017 and first published on 31 Oct 2017

Article type: Review Article
DOI: 10.1039/C7MD00449D
Med. Chem. Commun., 2017,8, 2023-2039

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    Benzisoxazole: a privileged scaffold for medicinal chemistry

    K. P. Rakesh, C. S. Shantharam, M. B. Sridhara, H. M. Manukumar and H. Qin, Med. Chem. Commun., 2017, 8, 2023
    DOI: 10.1039/C7MD00449D

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