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Issue 2, 2017
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A histone H1-binding-aptide-based apoptosis imaging probe for monitoring tumor responses to cancer therapy

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Abstract

Here we report the feasibility of using a high-affinity histone H1-binding peptide as a potential molecular apoptosis imaging probe. The Cy5.5-labeled peptide showed high selectivity for drug-treated apoptotic tumors compared with non-apoptotic tumors in various in vivo settings, enabling detection of tumor responses to both docetaxel chemotherapy and Herceptin antibody therapy as early as 12 hours after treatment with a high signal-to-background ratio, even at extremely low doses.

Graphical abstract: A histone H1-binding-aptide-based apoptosis imaging probe for monitoring tumor responses to cancer therapy

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Publication details

The article was received on 15 Dec 2016, accepted on 16 Dec 2016 and first published on 05 Jan 2017


Article type: Research Article
DOI: 10.1039/C6MD00696E
Med. Chem. Commun., 2017,8, 390-393

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    A histone H1-binding-aptide-based apoptosis imaging probe for monitoring tumor responses to cancer therapy

    Y. Lee, S. Kim, D. Kim and S. Jon, Med. Chem. Commun., 2017, 8, 390
    DOI: 10.1039/C6MD00696E

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