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Issue 3, 2017
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A review on cell wall synthesis inhibitors with an emphasis on glycopeptide antibiotics

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Abstract

Cell wall biosynthesis inhibitors (CBIs) have historically been one of the most effective classes of antibiotics. They are the most extensively used class of antibiotics and their importance is exemplified by the β-lactams and glycopeptide antibiotics. However, this class of antibiotics has not received impunity from resistance development. In the wake of this predicament, this review presents the progress of CBIs, especially glycopeptide derivatives as antibiotics to confront antibacterial resistance. The various strategies used for the development of CBIs, their clinical status and possible directions in which this field can evolve have also been discussed.

Graphical abstract: A review on cell wall synthesis inhibitors with an emphasis on glycopeptide antibiotics

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Article information


Submitted
21 Oct 2016
Accepted
18 Jan 2017
First published
26 Jan 2017

Med. Chem. Commun., 2017,8, 516-533
Article type
Review Article

A review on cell wall synthesis inhibitors with an emphasis on glycopeptide antibiotics

P. Sarkar, V. Yarlagadda, C. Ghosh and J. Haldar, Med. Chem. Commun., 2017, 8, 516
DOI: 10.1039/C6MD00585C

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