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Issue 24, 2017
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An acoustic on-chip goniometer for room temperature macromolecular crystallography

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Abstract

This paper describes the design, development and successful use of an on-chip goniometer for room-temperature macromolecular crystallography via acoustically induced rotations. We present for the first time a low cost, rate-tunable, acoustic actuator for gradual in-fluid sample reorientation about varying axes and its utilisation for protein structure determination on a synchrotron beamline. The device enables the efficient collection of diffraction data via a rotation method from a sample within a surface confined droplet. This method facilitates efficient macromolecular structural data acquisition in fluid environments for dynamical studies.

Graphical abstract: An acoustic on-chip goniometer for room temperature macromolecular crystallography

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Supplementary files

Article information


Submitted
01 Aug 2017
Accepted
01 Nov 2017
First published
01 Nov 2017

Lab Chip, 2017,17, 4225-4230
Article type
Communication

An acoustic on-chip goniometer for room temperature macromolecular crystallography

C. G. Burton, D. Axford, A. M. J. Edwards, R. J. Gildea, R. H. Morris, M. I. Newton, A. M. Orville, M. Prince, P. D. Topham and P. T. Docker, Lab Chip, 2017, 17, 4225 DOI: 10.1039/C7LC00812K

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