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Issue 8, 2017
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Separation and detection of gold nanoparticles with capillary electrophoresis and ICP-MS in single particle mode (CE-SP-ICP-MS)

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Abstract

In this work, we describe a method for the identification, separation, and detection of engineered nanoparticles (NPs) using capillary electrophoresis inductively coupled plasma-mass spectrometry in single particle mode (CE-SP-ICP-MS). Benefits of this method compared to conventional techniques include the fact that complex NPs mixtures are characterized on a particle-by-particle basis, separated with acceptable resolution, and in much shorter time. Information on particle number, particle mean size, size distribution, and elemental composition is obtained and visualized in three-dimensional single-particle electropherograms for the first time. The successful detection and characterization of single 10 nm-sized AuNPs with ICP-MS is demonstrated. Based on these results we believe that this method will become an important tool in high-throughput analysis, fractionation analysis, and in situ particle characterization.

Graphical abstract: Separation and detection of gold nanoparticles with capillary electrophoresis and ICP-MS in single particle mode (CE-SP-ICP-MS)

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Supplementary files

Article information


Submitted
27 Jan 2017
Accepted
22 Jun 2017
First published
23 Jun 2017

J. Anal. At. Spectrom., 2017,32, 1481-1489
Article type
Paper

Separation and detection of gold nanoparticles with capillary electrophoresis and ICP-MS in single particle mode (CE-SP-ICP-MS)

B. Franze, I. Strenge and C. Engelhard, J. Anal. At. Spectrom., 2017, 32, 1481 DOI: 10.1039/C7JA00040E

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