Gary N. Hermann, Celine L. Jung and Carsten Bolm
Green Chem., 2017,19, 2520-2523
DOI:
10.1039/C7GC00499K,
Communication
A mechanochemical indole synthesis by rhodium(III)-catalysed C–H bond functionalisation in a planetary mill has been developed. It occurs in the absence of any solvent, does not require additional heating and only needs catalytic quantities of Cu(OAc)2 in combination with dioxygen as a terminal oxidant. Accordingly, the process represents a powerful and environmentally benign alternative to the common solution-based standard protocols.
