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Issue 5, 2017
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Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

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Abstract

The one-pot multistep enzymatic oxidation of aliphatic and benzylic alcohols to the corresponding aldehydes combined with their subsequent carboligation to chiral α-hydroxy ketones has been exemplarily evaluated in terms of being a “green” biocatalytic approach. Besides the potential to start from bio-derived alcohols, this concept avoids the direct use of the reactive aldehyde intermediates, enables addition of high substrate concentrations in one liquid phase while maintaining enzyme activity and enables a simplified product isolation with diminished waste formation.

Graphical abstract: Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

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Publication details

The article was received on 03 Jan 2017, accepted on 31 Jan 2017 and first published on 31 Jan 2017


Article type: Communication
DOI: 10.1039/C7GC00020K
Citation: Green Chem., 2017,19, 1226-1229
  • Open access: Creative Commons BY-NC license
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    Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

    S. Schmidt, T. Pedroso de Almeida, D. Rother and F. Hollmann, Green Chem., 2017, 19, 1226
    DOI: 10.1039/C7GC00020K

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