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Issue 5, 2017
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Pd/C–Al–water facilitated selective reduction of a broad variety of functional groups

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Abstract

The chemoselective reduction of a broad variety of functional groups by a Pd/C–Al–H2O system is described. The reduction is based on the reaction of Al with the solvent water that in situ produces hydrogen that is utilized by the supported Pd catalyst toward the hydrogenation of the target functional groups. The hydrogenations are carried out under mild conditions and provided the products in high yields and selectivity. The reduction system appeared to be effective for a broad range of functional groups, including C–C, C–N, C–O and N–O multiple bonds, aromatic rings, hydrogenolysis of C–O, C–N and C–Halogen bonds. The appropriate selection of the reaction conditions allowed the selective preparation of different products from the same substrate. The simplicity, cost, tunability and the environmentally benign character of the catalytic system offer numerous advantages over the currently available methods.

Graphical abstract: Pd/C–Al–water facilitated selective reduction of a broad variety of functional groups

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Publication details

The article was received on 03 Nov 2016, accepted on 15 Dec 2016 and first published on 15 Dec 2016


Article type: Communication
DOI: 10.1039/C6GC03032G
Citation: Green Chem., 2017,19, 1230-1234

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    Pd/C–Al–water facilitated selective reduction of a broad variety of functional groups

    C. Schäfer, C. J. Ellstrom, H. Cho and B. Török, Green Chem., 2017, 19, 1230
    DOI: 10.1039/C6GC03032G

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