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Issue 5, 2017
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Purification, characterization and bioactivities of polysaccharides from Pleurotus ferulae

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Abstract

Pleurotus ferulae is an edible mushroom and has been used in Uygur medicine for a long time. In this study, we purified polysaccharides from P. ferulae (PFPS) and investigated its structural characteristics. We obtained a homogeneous PFPS with a molecular weight of around 1600 kDa and prominent characteristic polysaccharide groups, which mainly contained glucose (97%), followed by mannose and galactose (3%). Both 1H and 13C NMR spectra indicated that PFPS contained both α- and β-anomeric configurations. Atomic force microscopy and Congo red-staining data further suggested that PFPS belonged to a linear branched structure that existed in flexible single chains at low concentrations and could form aggregates such as a triple-helical structure at high concentrations. Moreover, PFPS promoted the maturation of dendritic cells through a TLR4 mediated signaling pathway, which is characterized by the increased expressions of CD40, CD86, IL-12 and TNF-α and the decreased endocytosis. The results suggest that PFPS has immunoregulatory activities.

Graphical abstract: Purification, characterization and bioactivities of polysaccharides from Pleurotus ferulae

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Supplementary files

Article information


Submitted
12 Feb 2017
Accepted
10 Apr 2017
First published
12 Apr 2017

Food Funct., 2017,8, 1905-1914
Article type
Paper

Purification, characterization and bioactivities of polysaccharides from Pleurotus ferulae

J. Li, P. Yuan, X. Wang, A. Aipire, M. Li, J. Yang, H. Tao, T. Ying, C. Fu, X. Wei, F. Zhang and J. Li, Food Funct., 2017, 8, 1905
DOI: 10.1039/C7FO00227K

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