Issue 42, 2017

Peptide-based fibrin-targeting probes for thrombus imaging

Abstract

The development of new methods to image the onset and progression of thrombosis is an unmet need. Non-invasive molecular imaging techniques targeting specific key structures involved in the formation of thrombosis have demonstrated the ability to detect thrombus in different disease state models and in patients. Due to its high concentration in the thrombus and its essential role in thrombus formation, the detection of fibrin is an attractive strategy for identification of thrombosis. Herein we provide an overview of recent and selected fibrin-targeted probes for molecular imaging of thrombosis by magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), and optical techniques. Emphasis is placed on work that our lab has explored over the last 15 years that has resulted in the progression of the fibrin-binding PET probe [64Cu]FBP8 from preclinical studies into human trials.

Graphical abstract: Peptide-based fibrin-targeting probes for thrombus imaging

Article information

Article type
Perspective
Submitted
20 Jul 2017
Accepted
12 Oct 2017
First published
12 Oct 2017

Dalton Trans., 2017,46, 14488-14508

Peptide-based fibrin-targeting probes for thrombus imaging

B. L. Oliveira and P. Caravan, Dalton Trans., 2017, 46, 14488 DOI: 10.1039/C7DT02634J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements