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Issue 42, 2017
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Metal complexes for multimodal imaging of misfolded protein-related diseases

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Abstract

Aggregation of misfolded proteins and progressive polymerization of otherwise soluble proteins is a common hallmark of a wide range of highly debilitating and increasingly prevalent diseases, including amyotrophic lateral sclerosis, cerebral amyloid angiopathy, type II diabetes and Parkinson's, Huntington's and Alzheimer's diseases. There is a growing interest in creating imaging agents to detect such aggregates in various imaging modalities, including PET, SPECT and MRI. We present here an overview of recent efforts from the perspective of early diagnosis of amyloid diseases, with a major focus on Aβ detection and metal complexes bearing PiB units.

Graphical abstract: Metal complexes for multimodal imaging of misfolded protein-related diseases

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Article information


Submitted
30 Jun 2017
Accepted
07 Sep 2017
First published
07 Sep 2017

Dalton Trans., 2017,46, 14461-14474
Article type
Perspective

Metal complexes for multimodal imaging of misfolded protein-related diseases

S. Lacerda, J.-F. Morfin, C. F. G. C. Geraldes and É. Tóth, Dalton Trans., 2017, 46, 14461
DOI: 10.1039/C7DT02371E

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