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Issue 42, 2017
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Structure and reactivities of rhenium and technetium bis-arene sandwich complexes [M(η6-arene)2]+

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Abstract

Sandwich complexes are important building blocks in medicinal inorganic chemistry for group 6 and 8 elements but are almost unknown for the manganese triad. We present the syntheses and full characterization of the mixed-arene 99Tc sandwich complexes [99Tc(η6-hmbz)(η6-C6H5–NH3)](PF6)2 and [99Tc(η6-hmbz)(η6-C6H5–Br)](PF6). Both comprise functionalities for conjugation to targeting molecules or for being included as substructures in pharmaceutically active lead compounds. Since η6-benzene ligands are too stably bound to be replaced with incoming ligands, we prepared naphthalene complexes [Re(η6-C6H6)(η6-napht)]+ and [Re(η6-napht)2]+. Their reactivities towards substitution are increased and one or both naphthalene ligands can be replaced with mono- or multi-dentate ligands. Combining the features of 99Tc and Re may lead to a molecule-based theranostic approach.

Graphical abstract: Structure and reactivities of rhenium and technetium bis-arene sandwich complexes [M(η6-arene)2]+

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Publication details

The article was received on 07 Jun 2017, accepted on 18 Jul 2017 and first published on 18 Jul 2017


Article type: Paper
DOI: 10.1039/C7DT02072D
Dalton Trans., 2017,46, 14631-14637

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    Structure and reactivities of rhenium and technetium bis-arene sandwich complexes [M(η6-arene)2]+

    G. Meola, H. Braband, S. Jordi, T. Fox, O. Blacque, B. Spingler and R. Alberto, Dalton Trans., 2017, 46, 14631
    DOI: 10.1039/C7DT02072D

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