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Issue 21, 2017
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Guanidinium-based “molecular glues” for modulation of biomolecular functions

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Abstract

Molecular adhesion based on multivalent interactions plays essential roles in various biological processes. Hence, “molecular glues” that can adhere to biomolecules may modulate biomolecular functions and therefore can be applied to therapeutics. This tutorial review describes design strategies for developing adhesive motifs for biomolecules based on multivalent interactions. We highlight a guanidinium ion-based salt-bridge as a key interaction for adhesion to biomolecules and discuss the application of molecular glues for manipulation of biomolecular assemblies, drug delivery systems, and modulation of biomolecular functions.

Graphical abstract: Guanidinium-based “molecular glues” for modulation of biomolecular functions

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Publication details

The article was received on 04 Sep 2017 and first published on 16 Oct 2017


Article type: Tutorial Review
DOI: 10.1039/C7CS00647K
Chem. Soc. Rev., 2017,46, 6480-6491

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    Guanidinium-based “molecular glues” for modulation of biomolecular functions

    R. Mogaki, P. K. Hashim, K. Okuro and T. Aida, Chem. Soc. Rev., 2017, 46, 6480
    DOI: 10.1039/C7CS00647K

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