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Issue 4, 2017
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Using titanium complexes to defeat cancer: the view from the shoulders of titans

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Abstract

When the first titanium complex with anticancer activity was identified in the 1970s, it was attractive, based on the presence of the dichloride unit in TiCl2Cp2 (Cp = η-C5H5)2, to assume its mode of biological action was closely aligned with cisplatin [cis-PtCl2(NH3)2]. Over the intervening 40 years however a far more complicated picture has arisen indicating multiple cellular mechanisms of cellular action can be triggered by titanium anti-cancer agents. This tutorial review aims to unpick the historical data and provide new researchers, without an explicit cancer biology background, a contemporary interpretation of both older and newer literature and to review the best techniques for attaining the identities of the biologically active titanium species and how these interact with the cancer cellular machinery.

Graphical abstract: Using titanium complexes to defeat cancer: the view from the shoulders of titans

  • This article is part of the themed collection: Primer
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Article information


Submitted
01 Dec 2016
First published
26 Jan 2017

Chem. Soc. Rev., 2017,46, 1040-1051
Article type
Tutorial Review
Author version available

Using titanium complexes to defeat cancer: the view from the shoulders of titans

M. Cini, T. D. Bradshaw and S. Woodward, Chem. Soc. Rev., 2017, 46, 1040
DOI: 10.1039/C6CS00860G

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