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Issue 41, 2017

Repelling and ordering: the influence of poly(ethylene glycol) on protein adsorption

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Abstract

Development of new materials for drug delivery and biosensing requires the fine-tuning of interfacial properties. We report here the influence of the poly(ethylene glycol) (PEG) grafting density in model phospholipid monolayers on the adsorption behavior of bovine serum albumin and human fibrinogen, not only with respect to the amount of adsorbed protein, but also its orientational ordering on the surface. As expected, with increasing interfacial PEG density, the amount of adsorbed protein decreases up to the point where complete protein repellency is reached. However, at intermediate concentrations, the net orientation of adsorbed fibrinogen is highest. The different proteins respond differently to PEG, not only in the amount of protein adsorbed, but also in the manner that proteins adsorb. The results show that for specific cases, tuning the interfacial PEG concentration allows to guide the protein adsorption configuration, a feature sought after in materials for both biosensing and biomedical applications.

Graphical abstract: Repelling and ordering: the influence of poly(ethylene glycol) on protein adsorption

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Article information


Submitted
10 Aug 2017
Accepted
03 Oct 2017
First published
09 Oct 2017

This article is Open Access

Phys. Chem. Chem. Phys., 2017,19, 28182-28188
Article type
Paper

Repelling and ordering: the influence of poly(ethylene glycol) on protein adsorption

C. Bernhard, S. J. Roeters, J. Franz, T. Weidner, M. Bonn and G. Gonella, Phys. Chem. Chem. Phys., 2017, 19, 28182 DOI: 10.1039/C7CP05445A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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