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Issue 39, 2017
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3D electrochemical and ion current imaging using scanning electrochemical–scanning ion conductance microscopy

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Abstract

Local cell-membrane permeability and ionic strength are important factors for maintaining the functions of cells. Here, we measured the spatial electrochemical and ion concentration profile near the sample surface with nanoscale resolution using scanning electrochemical microscopy (SECM) combined with scanning ion-conductance microscopy (SICM). The ion current feedback system is an effective way to control probe–sample distance without contact and monitor the kinetic effect of mediator regeneration and the chemical concentration profile. For demonstrating 3D electrochemical and ion concentration mapping, we evaluated the reaction rate of electrochemical mediator regeneration on an unbiased conductor and visualized inhomogeneous permeability and the ion concentration 3D profile on a single fixed adipocyte cell surface.

Graphical abstract: 3D electrochemical and ion current imaging using scanning electrochemical–scanning ion conductance microscopy

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Supplementary files

Article information


Submitted
31 Jul 2017
Accepted
19 Sep 2017
First published
19 Sep 2017

Phys. Chem. Chem. Phys., 2017,19, 26728-26733
Article type
Paper

3D electrochemical and ion current imaging using scanning electrochemical–scanning ion conductance microscopy

Y. Takahashi, H. Ida, Y. Matsumae, H. Komaki, Y. Zhou, A. Kumatani, M. Kanzaki, H. Shiku and T. Matsue, Phys. Chem. Chem. Phys., 2017, 19, 26728
DOI: 10.1039/C7CP05157C

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