Issue 17, 2017

The formation of two thiotriazoline polymorphs: study from the energetic viewpoint

Abstract

A comprehensive study of two polymorphic modifications of morpholin-4-ium 2-(5-methyl-1H-1,2,4-triazol-3-ylsulfanyl)acetate (trade mark “thiotriazoline”) within an approach based on the comparison of pairwise interaction energies has revealed the dependence of the crystal structure on the crystallization conditions. The orthorhombic modification is formed under kinetic control and has a more isotropic topology of intermolecular interaction energies. The building unit of the orthorhombic structure is a whole organic salt. The thermodynamically controlled crystallization causes the formation of the monoclinic modification with an anisotropic topology of interaction energies and the cation–anion pair dimer as a building unit. The main difference of the intermolecular interactions set within the two polymorphic modifications is associated with the presence or absence of non-charge-assisted hydrogen bonds with small enough energy.

Graphical abstract: The formation of two thiotriazoline polymorphs: study from the energetic viewpoint

Supplementary files

Article information

Article type
Paper
Submitted
16 Jan 2017
Accepted
27 Mar 2017
First published
28 Mar 2017

CrystEngComm, 2017,19, 2394-2401

The formation of two thiotriazoline polymorphs: study from the energetic viewpoint

S. V. Shishkina, V. N. Baumer, O. V. Khromileva, L. I. Kucherenko and I. A. Mazur, CrystEngComm, 2017, 19, 2394 DOI: 10.1039/C7CE00117G

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