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Issue 6, 2018
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Palladium-catalyzed enantioselective C(sp2)–H arylation of ferrocenyl ketones enabled by a chiral transient directing group

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Abstract

Palladium-catalyzed enantioselective C(sp2)–H activation of ferrocenyl ketones is achieved through utilizing catalytic, inexpensive L-tert-leucine as a chiral transient directing group. The transformation allows rapid access to ferrocene scaffolds simultaneously possessing planar- and stereogenic central chirality, widely applied in the ferrocene-based chiral ligand families.

Graphical abstract: Palladium-catalyzed enantioselective C(sp2)–H arylation of ferrocenyl ketones enabled by a chiral transient directing group

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Article information


Submitted
03 Dec 2017
Accepted
21 Dec 2017
First published
21 Dec 2017

Chem. Commun., 2018,54, 689-692
Article type
Communication

Palladium-catalyzed enantioselective C(sp2)–H arylation of ferrocenyl ketones enabled by a chiral transient directing group

J. Xu, Y. Liu, J. Zhang, X. Xu and Z. Jin, Chem. Commun., 2018, 54, 689
DOI: 10.1039/C7CC09273C

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