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Issue 6, 2018
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Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

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Abstract

A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosis.

Graphical abstract: Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

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Supplementary files

Article information


Submitted
30 Oct 2017
Accepted
21 Dec 2017
First published
21 Dec 2017

Chem. Commun., 2018,54, 658-661
Article type
Communication

Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

D. Bouzada, I. Salvadó, G. Barka, G. Rama, J. Martínez-Costas, R. Lorca, Á. Somoza, M. Melle-Franco, M. E. Vázquez and M. Vázquez López, Chem. Commun., 2018, 54, 658
DOI: 10.1039/C7CC08286J

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