Issue 100, 2017

A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

Abstract

We have developed a trifunctional cleavable fluorescence turn-ON linker for chemoproteomic applications. This novel linker, which became highly fluorescent only upon cleavage of the azo bond, was successfully used for in situ proteome profiling/target identification and studies on newly synthesised proteomes.

Graphical abstract: A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

Supplementary files

Article information

Article type
Communication
Submitted
25 Oct 2017
Accepted
24 Nov 2017
First published
24 Nov 2017

Chem. Commun., 2017,53, 13332-13335

A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

S. S. Liew, S. Du, J. Ge, S. Pan, S. Jang, J. Lee and S. Q. Yao, Chem. Commun., 2017, 53, 13332 DOI: 10.1039/C7CC08235E

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