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Issue 14, 2018
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Nickel-catalyzed amination of aryl fluorides with primary amines

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Abstract

The Ni-catalyzed cross-coupling reaction between aryl fluorides and primary amines was enabled by the 1,2-bis(dicyclohexylphosphino)benzene (DCYPBz) or 1,2-bis(dicyclohexylphosphino)ethane (DCYPE) ligands. Both N-alkyl- and N-aryl-substituted primary amines participated in the selective reaction to form secondary amines. This protocol would potentially be useful for late-stage diversification of fluorinated compounds with complex structures for the synthesis of functionally interesting aniline derivatives.

Graphical abstract: Nickel-catalyzed amination of aryl fluorides with primary amines

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Supplementary files

Article information


Submitted
23 Oct 2017
Accepted
12 Dec 2017
First published
12 Dec 2017

Chem. Commun., 2018,54, 1718-1721
Article type
Communication

Nickel-catalyzed amination of aryl fluorides with primary amines

T. Harada, Y. Ueda, T. Iwai and M. Sawamura, Chem. Commun., 2018, 54, 1718
DOI: 10.1039/C7CC08181B

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