Jun-Kee Cheng, Liang Shen, Liu-Hai Wu, Xu-Hong Hu and Teck-Peng Loh
Chem. Commun., 2017,53, 12830-12833
DOI:
10.1039/C7CC08074C,
Communication
A reaction protocol in which FeCl3 and tert-butyl hydroperoxide facilitated a selective radical coupling reaction of aryl alkenes or 1,3-enynes with tert-butyl hydroperoxide and formamides to prepare an array of β-peroxy amides has been achieved. The β-peroxy amide could serve as a synthetic precursor which was facilely converted to β-hydroxy amide, β-keto amide and β-lactam following subsequent chemical transformation.