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Issue 100, 2017
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Advances in single quantum dot-based nanosensors

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Single-molecule detection provides a simple and ultrasensitive platform to quantify target molecules by simply counting the individual fluorescence signals. Quantum dots (QDs) are novel semiconductor nanocrystals with distinct characteristics of high brightness, large Stokes shift and broad absorption spectra, high molar extinction coefficients, high quantum yield, good photostability and long fluorescence lifetime. The combination of single-molecule detection with QDs enables the development of single QD-based nanosensors with extremely high sensitivity. Single QD-based nanosensors may be divided into two categories based on single QD burst coincidence detection and single QD-fluorescence resonance energy transfer (FRET) detection, and have significant advantages of high signal-to-noise ratio, high sensitivity, rapidity, and low sample consumption. The single QD-based nanosensors have the capability of directly detecting low-abundance species without the need for nucleic acid amplification, and may elucidate a variety of biological and biochemical phenomena in real time using single QD tracking. In this review, we summarize the recent advances in single QD-based nanosensors and their applications for sensitive detection of DNAs, microRNAs, proteins, enzymes, small molecules and viruses. We highlight the challenges and future direction of single QD-based nanosensors as well.

Graphical abstract: Advances in single quantum dot-based nanosensors

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Publication details

The article was received on 06 Oct 2017, accepted on 17 Nov 2017 and first published on 17 Nov 2017

Article type: Feature Article
DOI: 10.1039/C7CC07752A
Citation: Chem. Commun., 2017,53, 13284-13295
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    Advances in single quantum dot-based nanosensors

    J. Hu, Z. Wang, C. Li and C. Zhang, Chem. Commun., 2017, 53, 13284
    DOI: 10.1039/C7CC07752A

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