Bo Huang, Linwei Zeng, Yangyong Shen and Sunliang Cui
Chem. Commun., 2017,53, 11996-11999
DOI:
10.1039/C7CC07055A,
Communication
A nickel-catalyzed acetamidation and lactamization of arylboronic acids via a one-pot reaction with ynamides and N-hydroxyphthalimide is described. This protocol features with mild reaction conditions and a broad substrate scope, and has been successfully applied to late-stage functionalization of pharmaceuticals. Moreover, control reactions were conducted to elucidate a plausible mechanism.
