Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography†
G.
Mazzoccanti, 
a
O. H.
Ismail,
a
I.
D’Acquarica,
*a
C.
Villani,
a
A.
Cavazzini
d
and
F.
Gasparrini
*a
a
O. H.
Ismail,
a
I.
D’Acquarica,
*a
C.
Villani,
a
A.
Cavazzini
d
and
F.
Gasparrini
*a
Abstract
By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (−)-Δ9-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity.
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