Selective cytotoxicity and luminescence imaging of cancer cells with a dipicolinato-based EuIII complex

J. H. S. K. Monteiro; D. Machado; L. M. de Hollanda; M. Lancellotti; F. A. Sigoli; A. de Bettencourt-Dias

doi:10.1039/C7CC06753D

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Selective cytotoxicity and luminescence imaging of cancer cells with a dipicolinato-based Eu^III complex†

J. H. S. K. Monteiro,^ab D. Machado,^c L. M. de Hollanda,^c M. Lancellotti,^c F. A. Sigoli*^a and A. de Bettencourt-Dias

*^b

Author affiliations

* Corresponding authors

^a Institute of Chemistry, University of Campinas, São Paulo, Brazil
E-mail: fsigoli@iqm.unicamp.br

^b Department of Chemistry, University of Nevada, Reno, NV 89557
E-mail: abd@unr.edu

^c Institute of Biology, University of Campinas, São Paulo, Brazil

Abstract

Four new species [Ln(dipicNH₂)₃]³⁻ (Ln = La^III, Eu^III, Gd^III, Tb^III), with the ligand dipicNH₂²⁻ (dipic = dipicolinato), were synthesized. Incubation of the Eu^III complex with glioma NG97 and pancreatic cancer PANC1 cells showed that it penetrates the cell membrane and can be used to image the cells, while also being moderately cytotoxic.

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Article information

DOI: https://doi.org/10.1039/C7CC06753D
Article type: Communication
Submitted: 28 Aug 2017
Accepted: 09 Oct 2017
First published: 17 Oct 2017

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Chem. Commun., 2017,53, 11818-11821

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Selective cytotoxicity and luminescence imaging of cancer cells with a dipicolinato-based Eu^III complex

J. H. S. K. Monteiro, D. Machado, L. M. de Hollanda, M. Lancellotti, F. A. Sigoli and A. de Bettencourt-Dias, Chem. Commun., 2017, 53, 11818 DOI: 10.1039/C7CC06753D

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