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Issue 89, 2017
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Thermo-responsive self-immolative nanoassemblies: direct and indirect triggering

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Abstract

A thermo-responsive end-cap based on a retro-Diels–Alder and subsequent furan elimination reaction was developed. It was used to cap poly(ethyl glyoxylate), allowing end-to-end depolymerization upon thermal triggering. Using block copolymers, thermo-responsive micelles and vesicles were prepared and shown to disassemble upon heating. Thermal degradation could also be triggered indirectly by magnetic field hyperthermia after incorporation of iron oxide nanoparticles into the assemblies.

Graphical abstract: Thermo-responsive self-immolative nanoassemblies: direct and indirect triggering

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Supplementary files

Article information


Submitted
16 Aug 2017
Accepted
05 Oct 2017
First published
06 Oct 2017

Chem. Commun., 2017,53, 12068-12071
Article type
Communication

Thermo-responsive self-immolative nanoassemblies: direct and indirect triggering

B. Fan, J. F. Trant, G. Hemery, O. Sandre and E. R. Gillies, Chem. Commun., 2017, 53, 12068
DOI: 10.1039/C7CC06410A

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