A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents

Nikki L. Sloan; Sajinder K. Luthra; Graeme McRobbie; Sally L. Pimlott; Andrew Sutherland

doi:10.1039/C7CC06211G

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of ¹²⁵I-imaging agents†

Nikki L. Sloan,^a Sajinder K. Luthra,^b Graeme McRobbie,^b Sally L. Pimlott^c and Andrew Sutherland

*^a

Author affiliations

* Corresponding authors

^a WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
E-mail: Andrew.Sutherland@glasgow.ac.uk
Fax: +44 (0)141 330 4888
Tel: +44 (0)141 330 5936

^b GE Healthcare, The Grove Centre, White Lion Road, Amersham, UK

^c West of Scotland PET Centre, Greater Glasgow and Clyde NHS Trust, Glasgow G12 0YN, UK

Abstract

An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of ¹²⁵I-labelled aryl compounds and SPECT radiotracers.

Download options Please wait...

Supplementary files

Supplementary information PDF (6452K)

Article information

DOI: https://doi.org/10.1039/C7CC06211G
Article type: Communication
Submitted: 09 Aug 2017
Accepted: 23 Aug 2017
First published: 24 Aug 2017
This article is Open Access

Download Citation

Chem. Commun., 2017,53, 11008-11011

Permissions

Request permissions

A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of ¹²⁵I-imaging agents

N. L. Sloan, S. K. Luthra, G. McRobbie, S. L. Pimlott and A. Sutherland, Chem. Commun., 2017, 53, 11008 DOI: 10.1039/C7CC06211G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications