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Issue 80, 2017
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A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents†

Nikki L. Sloan,a   Sajinder K. Luthra,b   Graeme McRobbie,b   Sally L. Pimlottc  and  Andrew Sutherland ORCID logo *a  
Author affiliations

* Corresponding authors

a WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
E-mail: Andrew.Sutherland@glasgow.ac.uk
Fax: +44 (0)141 330 4888
Tel: +44 (0)141 330 5936

b GE Healthcare, The Grove Centre, White Lion Road, Amersham, UK

c West of Scotland PET Centre, Greater Glasgow and Clyde NHS Trust, Glasgow G12 0YN, UK

Abstract

An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of 125I-labelled aryl compounds and SPECT radiotracers.

Graphical abstract: A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents

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Article information

https://doi.org/10.1039/C7CC06211G
Submitted
09 Aug 2017
Accepted
23 Aug 2017
First published
24 Aug 2017
This article is Open Access
Creative Commons BY license
Chem. Commun., 2017,53, 11008-11011
Article type
Communication
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A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents

N. L. Sloan, S. K. Luthra, G. McRobbie, S. L. Pimlott and A. Sutherland, Chem. Commun., 2017, 53, 11008
DOI: 10.1039/C7CC06211G

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