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Issue 80, 2017
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Intracellular temperature measurements with fluorescent polymeric thermometers

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In 2003, we successfully created the first fluorescent polymeric thermometer by combining a thermo-responsive polymer and an environment-sensitive (polarity and hydrogen bonding-sensitive) fluorophore. Its high sensitivity to temperature variation and high hydrophilicity, even under conditions of high ionic strength, enabled intracellular temperature measurements. Along with the progress of our research projects, the development of new luminescent molecular thermometers and the establishment of novel methods for measuring intracellular temperature have matured in this field. In this Feature Article, we summarize the background and history of intracellular temperature measurements using fluorescent polymeric thermometers based on studies performed in our laboratory and the relationship between our methods and those of other eminent research groups. Future research directions regarding intracellular temperature measurements are also discussed.

Graphical abstract: Intracellular temperature measurements with fluorescent polymeric thermometers

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Publication details

The article was received on 08 Aug 2017, accepted on 01 Sep 2017 and first published on 01 Sep 2017

Article type: Feature Article
DOI: 10.1039/C7CC06203F
Citation: Chem. Commun., 2017,53, 10976-10992

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    Intracellular temperature measurements with fluorescent polymeric thermometers

    S. Uchiyama, C. Gota, T. Tsuji and N. Inada, Chem. Commun., 2017, 53, 10976
    DOI: 10.1039/C7CC06203F

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