Christoph Nitsche, Mithun C. Mahawaththa, Walter Becker, Thomas Huber and Gottfried Otting
Chem. Commun., 2017,53, 10894-10897
DOI:
10.1039/C7CC06155B,
Communication
Site-selective chemical protein modification is achieved by self-assembly of a specific di-cysteine motif, trivalent pnictogens (As, Sb or Bi) and an aromatic mercaptomethyl-based probe. The strategy is demonstrated with a quaternary complex involving Zika virus protease and a lanthanide ion, enabling paramagnetic nuclear magnetic resonance spectroscopy and luminescence measurements.
