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Issue 87, 2017
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Programmable fusion of liposomes mediated by lipidated PNA

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Abstract

We recently reported a DNA-programmed fusion cascade enabling the use of liposomes as nanoreactors for compartmentalized chemical reactions. This communication reports an alternative and robust strategy based on lipidated peptide nucleic acids (LiPs). LiPs enabled fusion of liposomes with remarkable 31% efficiency at 50 °C with low leakage (5%).

Graphical abstract: Programmable fusion of liposomes mediated by lipidated PNA

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Supplementary files

Article information


Submitted
03 Aug 2017
Accepted
11 Oct 2017
First published
11 Oct 2017

Chem. Commun., 2017,53, 11921-11924
Article type
Communication

Programmable fusion of liposomes mediated by lipidated PNA

A. Rabe, P. M. G. Löffler, O. Ries and S. Vogel, Chem. Commun., 2017, 53, 11921
DOI: 10.1039/C7CC06058K

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