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Issue 77, 2017
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Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

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Abstract

Macrocyclic peptides have promising therapeutic potential but the scaling up of their chemical synthesis is challenging. The cyanobactin macrocyclase PatGmac is an efficient tool for production but is limited to substrates containing 6–11 amino acids and at least one thiazoline or proline. Here we report a new cyanobactin macrocyclase that can cyclize longer peptide substrates and those not containing proline/thiazoline and thus allows exploring a wider chemical diversity.

Graphical abstract: Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

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Supplementary files

Article information


Submitted
28 Jul 2017
Accepted
05 Sep 2017
First published
11 Sep 2017

This article is Open Access

Chem. Commun., 2017,53, 10656-10659
Article type
Communication

Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

C. N. Alexandru-Crivac, C. Umeobika, N. Leikoski, J. Jokela, K. A. Rickaby, A. M. Grilo, P. Sjö, A. T. Plowright, M. Idress, E. Siebs, A. Nneoyi-Egbe, M. Wahlsten, K. Sivonen, M. Jaspars, L. Trembleau, D. P. Fewer and W. E. Houssen, Chem. Commun., 2017, 53, 10656
DOI: 10.1039/C7CC05913B

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