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Issue 78, 2017
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A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

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Abstract

A fluorescent probe that enables ratiometric imaging of endogenous hypochlorous acid (HOCl) in cells and tissues by two-photon microscopy is developed based on a red-emitting acetyl-benzocoumarin (AcBC) dye. An oxathiolane group in the probe reacts with HOCl to generate the AcBC dye, which involves a ratiometric fluorescence change only toward HOCl along with high sensitivity.

Graphical abstract: A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

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Supplementary files

Article information


Submitted
26 Jul 2017
Accepted
06 Sep 2017
First published
06 Sep 2017

Chem. Commun., 2017,53, 10800-10803
Article type
Communication

A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

Y. W. Jun, S. Sarkar, S. Singha, Y. J. Reo, H. R. Kim, J. Kim, Y. Chang and K. H. Ahn, Chem. Commun., 2017, 53, 10800
DOI: 10.1039/C7CC05834A

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