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Issue 75, 2017
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Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation

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Abstract

Here we report a set of direct functionalization methods of unmasked 2-phenylquinazolin-4(3H)-ones, a privileged alkaloid core, without the installation/removal event of protecting groups or exogenous coordinating moieties. Divergent pathways were modulated with transition-metal catalysts by suppressing competitive reactivities, leading to N-arylation, annulative π-extension, or C–H fluorination.

Graphical abstract: Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation

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Article information


Submitted
25 Jul 2017
Accepted
29 Aug 2017
First published
29 Aug 2017

Chem. Commun., 2017,53, 10394-10397
Article type
Communication

Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation

J. B. Lee, M. E. Kang, J. Kim, C. Y. Lee, J. Kee, K. Myung, J. Park and S. Y. Hong, Chem. Commun., 2017, 53, 10394
DOI: 10.1039/C7CC05794F

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